IL17D

Across TCGA cell cohorts, IL17D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL17D-associated GO terms across cancer lineages are Megakaryocyte differentiation, Positive regulation of cell-substrate junction organization, and T cell receptor signaling pathway. Each is linked with IL17D in more than 10 cancer types. Because this analysis shows association rather than direction, both IL17D-to-partner and partner-to-IL17D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Megakaryocyte differentiation grouped by IL17D-low versus IL17D-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17D→partner) and Y-score (partner→IL17D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Megakaryocyte differentiation →	-0.200	-1.463	.003	.002	3	11
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	-0.119	-1.261	.003	<.001	3	10
KIDNEY	T cell receptor signaling pathway →	-0.055	-0.557	.004	.006	2	11
STOMACH	Copper ion export →	-0.142	-1.140	.001	.001	3	9
LIVER	Epithelial cell fate commitment →	-0.229	-1.358	<.001	.008	3	9
LUNG_SCLC	Regulation of calcium ion transport into cytosol →	-0.214	-1.097	.002	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

Megakaryocyte differentiation by IL17D expression — LIVER

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