IL16

Across TCGA patient cohorts, IL16 mutation is significantly associated with the RNA expression of many other genes, with 6,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL16-associated genes across cancer lineages are ALKBH2, BSPRY, and CCNB1. Each is linked with IL16 in more than 4 cancer types. Because this analysis shows association rather than direction, both IL16-to-partner and partner-to-IL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALKBH2 grouped by IL16-low versus IL16-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL16→partner) and Y-score (partner→IL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ALKBH2 →	+0.458	+2.450	.001	.001	3	5
COAD	BSPRY →	+0.559	+2.920	<.001	.001	3	5
UCEC	CCNB1 →	+0.684	+1.932	<.001	<.001	3	5
UCEC	PSMC3IP →	+0.603	+1.943	<.001	<.001	3	4
UCEC	FAM151B →	+0.171	+1.450	.007	.004	3	4
UCEC	CENPH →	+0.533	+1.943	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,105 associations by consensus.

ALKBH2 by IL16 expression — LUAD

Explore this box plot interactively →