IL16

Across TCGA patient cohorts, IL16 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL16-associated genes across cancer lineages are Cyclin-B1, C-Raf_pS338, and Rad50. Each is linked with IL16 in more than 4 cancer types. Because this analysis shows association rather than direction, both IL16-to-partner and partner-to-IL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by IL16-low versus IL16-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL16→partner) and Y-score (partner→IL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.679	+3.016	.008	.018	3	5
STAD	C-Raf_pS338 →	-0.160	-2.321	.004	.032	3	4
UCEC	Rad50 →	-0.155	-2.074	.018	.004	3	4
UCEC	TFRC →	+0.477	+2.247	<.001	.001	3	4
UCEC	STAT3_pY705 →	-0.320	-1.690	<.001	.001	3	3
LUAD	FoxM1 →	+0.277	+3.012	.040	.018	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Cyclin-B1 by IL16 expression — COAD

Explore this box plot interactively →