IL16

Across TCGA cell cohorts, IL16 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,332 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IL16-associated GO terms across cancer lineages are Positive regulation of mitophagy, Protein targeting, and Positive regulation of interleukin-1 alpha production. Each is linked with IL16 in more than 8 cancer types. Because this analysis shows association rather than direction, both IL16-to-partner and partner-to-IL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitophagy grouped by IL16-low versus IL16-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL16→partner) and Y-score (partner→IL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of mitophagy →	+0.094	+0.300	<.001	.001	2	9
PANCREAS	Protein targeting →	+0.037	+0.405	.007	.001	3	7
CNS	Positive regulation of interleukin-1 alpha production →	-0.240	-0.942	<.001	<.001	3	6
SKIN	Negative regulation of transcription by RNA polymerase III →	+0.112	+1.624	<.001	<.001	3	6
PANCREAS	Regulation of cellular response to heat →	+0.088	+0.320	<.001	.005	3	6
LARGE_INTESTINE	Regulation of response to endoplasmic reticulum stress →	+0.043	+0.315	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,332 associations by consensus.

Positive regulation of mitophagy by IL16 expression — OESOPHAGUS

Explore this box plot interactively →