IL16

Across TCGA cell cohorts, IL16 mutation is significantly associated with the mutation status of many other genes, with 5,469 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL16-associated genes across cancer lineages are BCL11B, OVCH1, and ACO1. Each is linked with IL16 in more than 5 cancer types. Because this analysis shows association rather than direction, both IL16-to-partner and partner-to-IL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL11B grouped by IL16-low versus IL16-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL16→partner) and Y-score (partner→IL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BCL11B →	+5.502	+5.502	.003	.003	1	6
SOFT_TISSUE	OVCH1 →	+5.502	+5.502	.003	.003	1	5
BLOOD_Leukemia	ACO1 →	+4.794	+3.309	.002	.002	1	5
LARGE_INTESTINE	LRFN1 →	+1.886	+1.756	.004	.004	1	5
LARGE_INTESTINE	ADAMTS19 →	+2.693	+2.440	<.001	<.001	1	5
LARGE_INTESTINE	SRRM2 →	+1.556	+1.794	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,469 associations by consensus.

BCL11B by IL16 expression — SOFT_TISSUE

Explore this box plot interactively →