IL13RA2

Across TCGA pan-cancer cohorts, IL13RA2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL13RA2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IL13RA2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL13RA2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

KIRP, ACC, and LGG are the cancer types where IL13RA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.797	0.942	.001	60	view →
ACC	DFS	Quartile	All	0.140	0.768	<.001	52	view →
LGG	OS	Median	All	0.718	0.904	<.001	52	view →
LUAD	DFS	Tertile	II,III,IV	0.772	0.604	.013	50	view →
PAAD	DFS	Median	All	0.561	0.403	.002	30	view →
COAD	DFS	Median	All	0.831	0.733	.001	30	view →
SCLC	OS	Median	II,III,IV	0.462	1.000	.005	24	view →
READ	DFS	Median	IV	0.794	0.353	.003	18	view →
CHOL	OS	Tertile	II,III,IV	0.818	0.330	.009	16	view →
THCA	OS	Tertile	II,III,IV	0.962	1.000	.012	15	view →
KIRC	DFS	Median	III,IV	0.768	0.488	<.001	14	view →
STAD	OS	Quartile	All	0.594	0.846	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL13RA2–KIRP (DFS)

Open the KIRP breakdown →