IL12RB2

Across TCGA patient cohorts, IL12RB2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12RB2-associated genes across cancer lineages are ASNS, Notch1, and p38-MAPK_pT180_Y182. Each is linked with IL12RB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL12RB2-to-partner and partner-to-IL12RB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IL12RB2-low versus IL12RB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB2→partner) and Y-score (partner→IL12RB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.420	+2.000	.001	.029	3	3
UCEC	Notch1 →	+0.148	+1.502	.004	.030	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.483	-2.807	.003	.003	3	2
UCEC	PCNA →	+0.203	+3.169	.010	.018	3	2
UCEC	Shc_pY317 →	-0.189	-2.000	<.001	.030	3	2
UCEC	c-Met_pY1235 →	+0.054	+1.502	.046	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ASNS by IL12RB2 expression — UCEC

Explore this box plot interactively →