IL12RB2

Across TCGA cell cohorts, IL12RB2 mutation is significantly associated with the RNA expression of many other genes, with 1,007 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL12RB2-associated genes across cancer lineages are PDHA2, RD3L, and GRM6. Each is linked with IL12RB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL12RB2-to-partner and partner-to-IL12RB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDHA2 grouped by IL12RB2-low versus IL12RB2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB2→partner) and Y-score (partner→IL12RB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDHA2 →	+0.026	+5.029	<.001	.006	3	1
LUNG_SCLC	RD3L →	+0.018	+5.029	.004	.006	3	1
BLOOD_Leukemia	GRM6 →	+0.029	+3.855	.002	.007	3	1
BLOOD_Leukemia	DEFB131B →	+0.190	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IFNA14 →	+0.098	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR52B2 →	+0.033	+4.450	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,007 associations by consensus.

PDHA2 by IL12RB2 expression — LUNG_SCLC

Explore this box plot interactively →