IL12RB1

Across TCGA patient cohorts, IL12RB1 protein abundance is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IL12RB1-associated genes across cancer lineages are SLC6A13, H2AZ2, and ECM2. Each is linked with IL12RB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL12RB1-to-partner and partner-to-IL12RB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL12RB1 versus SLC6A13 in LSCC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB1→partner) and Y-score (partner→IL12RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC6A13 →	+0.549	+0.785	.006	.009	3	1
LSCC	H2AZ2 →	-0.574	-0.850	<.001	.001	3	1
LSCC	ECM2 →	-0.443	-0.561	.006	.008	3	1
LSCC	VEGFA →	-0.752	-0.800	<.001	.003	3	1
LSCC	CD48 →	+0.729	+0.691	.002	.008	3	1
LSCC	CPN1 →	+0.259	+0.788	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

IL12RB1 vs SLC6A13 — LSCC

Explore this scatter interactively →