IL12RB1

Across TCGA patient cohorts, IL12RB1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12RB1-associated genes across cancer lineages are ATM, IRS1, and Caspase-8. Each is linked with IL12RB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL12RB1-to-partner and partner-to-IL12RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by IL12RB1-low versus IL12RB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB1→partner) and Y-score (partner→IL12RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.362	-1.986	.010	.008	3	3
SKCM	IRS1 →	+0.252	+2.906	<.001	.001	3	2
UCEC	Caspase-8 →	-0.209	-2.295	.007	<.001	3	2
UCEC	JNK2 →	+0.164	+1.201	.008	.028	3	2
UCEC	Cyclin-B1 →	+0.410	+2.700	.018	.005	3	2
SKCM	G6PD →	-0.242	-3.584	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by IL12RB1 expression — UCEC

Explore this box plot interactively →