IL12RB1

Across TCGA cell cohorts, IL12RB1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL12RB1-associated genes across cancer lineages are PPIAL4E, HELT, and SLC32A1. Each is linked with IL12RB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL12RB1-to-partner and partner-to-IL12RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4E grouped by IL12RB1-low versus IL12RB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB1→partner) and Y-score (partner→IL12RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPIAL4E →	+0.036	+5.643	<.001	.002	3	1
CNS	HELT →	+0.037	+5.321	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.736	+3.771	<.001	.004	3	1
BLOOD_Leukemia	CHST9 →	+0.020	+3.551	<.001	.008	3	1
BLOOD_Leukemia	DIRAS2 →	+0.075	+3.551	<.001	.008	3	1
BLOOD_Leukemia	KCNC2 →	+0.113	+3.771	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PPIAL4E by IL12RB1 expression — LUNG_SCLC

Explore this box plot interactively →