IL11RA

Across TCGA patient cohorts, IL11RA mutation is significantly associated with the RNA expression of many other genes, with 1,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL11RA-associated genes across cancer lineages are PFAS, CTC1, and PRF1. Each is linked with IL11RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL11RA-to-partner and partner-to-IL11RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFAS grouped by IL11RA-low versus IL11RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL11RA→partner) and Y-score (partner→IL11RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFAS →	+0.517	+3.617	.001	.001	3	2
UCEC	CTC1 →	+0.368	+2.343	.006	<.001	3	2
UCEC	PRF1 →	+0.753	+2.815	.006	.001	3	2
UCEC	RPL23AP82 →	+0.362	+1.936	.001	.003	3	2
UCEC	INSIG1 →	+0.745	+1.947	<.001	.003	3	2
UCEC	C1orf174 →	+0.396	+2.743	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,713 associations by consensus.

PFAS by IL11RA expression — UCEC

Explore this box plot interactively →