IL11RA

Across TCGA patient cohorts, IL11RA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL11RA-associated genes across cancer lineages are PDCD4, IGFBP2, and JNK2. Each is linked with IL11RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL11RA-to-partner and partner-to-IL11RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by IL11RA-low versus IL11RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL11RA→partner) and Y-score (partner→IL11RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.400	-1.678	.026	.023	3	2
UCEC	IGFBP2 →	-0.541	-2.321	.029	.034	3	1
UCEC	JNK2 →	+0.274	+2.584	<.001	.001	3	1
UCEC	MEK1 →	+0.307	+1.906	.028	.015	3	1
UCEC	MSH2 →	-0.296	-2.558	<.001	.010	3	1
UCEC	p27_pT157 →	-0.044	-1.661	.048	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PDCD4 by IL11RA expression — UCEC

Explore this box plot interactively →