IL10RB

Across TCGA pan-cancer cohorts, IL10RB mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IL10RB’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where IL10RB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IL10RB is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where IL10RB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL10RB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.704	<.001	9	view →
LSCC	All	All	−0.156	.003	4	view →
PDAC	All	III,IV	+0.468	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IL10RB–CCRCC

Open the CCRCC breakdown →