IL10RB

Across TCGA patient cohorts, IL10RB mutation is significantly associated with the RNA expression of many other genes, with 1,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL10RB-associated genes across cancer lineages are ATP6V0E1P4, ATP5MGP4, and SNX18P9. Each is linked with IL10RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL10RB-to-partner and partner-to-IL10RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V0E1P4 grouped by IL10RB-low versus IL10RB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10RB→partner) and Y-score (partner→IL10RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATP6V0E1P4 →	+0.268	+4.372	.001	.007	3	2
SKCM	ATP5MGP4 →	+0.098	+3.533	.001	.007	3	2
UCEC	SNX18P9 →	+0.103	+1.800	.001	.005	3	2
BRCA	MIR6737 →	+0.608	+5.506	<.001	.005	3	1
UCEC	INTS4 →	+0.314	+3.470	.009	.002	3	1
UCEC	LAMTOR1 →	+0.367	+2.513	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,561 associations by consensus.

ATP6V0E1P4 by IL10RB expression — LUAD

Explore this box plot interactively →