IL10RB

Across TCGA patient cohorts, IL10RB mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL10RB-associated genes across cancer lineages are EGFR, eIF4E, and INPP4B. Each is linked with IL10RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL10RB-to-partner and partner-to-IL10RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by IL10RB-low versus IL10RB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10RB→partner) and Y-score (partner→IL10RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.195	-3.000	.003	.036	3	1
UCEC	eIF4E →	+0.183	+2.183	.035	.033	3	1
UCEC	INPP4B →	-0.305	-3.459	.022	.005	3	1
UCEC	JNK2 →	+0.222	+3.000	.006	.001	3	1
UCEC	MEK1 →	+0.556	+3.807	<.001	<.001	3	1
UCEC	Myosin-IIa →	+0.214	+1.707	.006	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR by IL10RB expression — UCEC

Explore this box plot interactively →