IL10

Across TCGA patient cohorts, IL10 mutation is significantly associated with the RNA expression of many other genes, with 758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL10-associated genes across cancer lineages are OR5J7P, RNU6-1305P, and OR5AU1. Each is linked with IL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL10-to-partner and partner-to-IL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5J7P grouped by IL10-low versus IL10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10→partner) and Y-score (partner→IL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR5J7P →	+0.178	+7.741	<.001	.009	3	2
BLCA	RNU6-1305P →	+0.371	+5.106	<.001	.008	3	2
SCLC	OR5AU1 →	+0.069	+4.047	.001	.004	3	1
SCLC	MAGEB16 →	+0.561	+5.108	.002	<.001	3	1
SCLC	KRTAP4-5 →	+0.088	+4.432	<.001	.001	3	1
SCLC	KRTAP3-2 →	+1.282	+3.712	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

OR5J7P by IL10 expression — COAD

Explore this box plot interactively →