IL10

Across TCGA cell cohorts, IL10 RNA expression is significantly associated with the go_rna of many other GO terms, with 829 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL10-associated GO terms across cancer lineages are Response to carbon monoxide, Regulation of type B pancreatic cell apoptotic process, and Regulation of plasma cell differentiation. Each is linked with IL10 in more than 5 cancer types. Because this analysis shows association rather than direction, both IL10-to-partner and partner-to-IL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to carbon monoxide grouped by IL10-low versus IL10-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL10→partner) and Y-score (partner→IL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Response to carbon monoxide →	-0.216	-1.717	<.001	<.001	3	6
LARGE_INTESTINE	Regulation of type B pancreatic cell apoptotic process →	+0.121	+0.994	<.001	.007	3	4
BLOOD_Leukemia	Regulation of plasma cell differentiation →	-0.170	-0.805	.001	<.001	3	4
URINARY_TRACT	Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	+0.190	+0.020	.003	.006	3	4
SKIN	Negative regulation of MHC class II biosynthetic process →	-0.176	-0.758	<.001	<.001	3	4
BLOOD_Leukemia	Response to ozone →	-0.114	-0.479	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 829 associations by consensus.

Response to carbon monoxide by IL10 expression — LARGE_INTESTINE

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