IKZF5

Across TCGA pan-cancer cohorts, IKZF5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IKZF5 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IKZF5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IKZF5 expression acts as an unfavorable survival marker.

HNSC, COAD, and CHOL are the cancer types where IKZF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.169	0.751	<.001	42	view →
COAD	DFS	Median	All	0.134	0.794	<.001	24	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IKZF5–HNSC (OS)

Open the HNSC breakdown →