IKZF5

Across TCGA pan-cancer cohorts, IKZF5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IKZF5 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IKZF5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IKZF5 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, LUAD, and GBM are the cancer types where IKZF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.294	0.811	.030	11	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.615	.040	4	view →
GBM	DFS	Quartile	All	0.341	0.632	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IKZF5–PDAC (OS)

Open the PDAC breakdown →