IKZF5

Across TCGA patient cohorts, IKZF5 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF5-associated genes across cancer lineages are JNK2, Ku80, and Notch1. Each is linked with IKZF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF5-to-partner and partner-to-IKZF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IKZF5-low versus IKZF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF5→partner) and Y-score (partner→IKZF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.254	+2.321	.010	.035	3	1
UCEC	Ku80 →	+0.329	+3.013	.005	.018	3	1
UCEC	Notch1 →	+0.143	+2.321	.044	.035	3	1
UCEC	STAT3_pY705 →	-0.529	-2.321	<.001	.033	3	1
UCEC	Caspase-8 →	-0.273	-2.321	.031	.034	3	1
UCEC	cIAP →	+0.145	+2.179	.035	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by IKZF5 expression — UCEC

Explore this box plot interactively →