IKZF5

Across TCGA cell cohorts, IKZF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,968 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IKZF5-associated GO terms across cancer lineages are Regulation of sister chromatid cohesion, Protein modification by small protein removal, and Viral translational termination-reinitiation. Each is linked with IKZF5 in more than 12 cancer types. Because this analysis shows association rather than direction, both IKZF5-to-partner and partner-to-IKZF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sister chromatid cohesion grouped by IKZF5-low versus IKZF5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF5→partner) and Y-score (partner→IKZF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.129	+0.590	.001	.001	3	12
SOFT_TISSUE	Protein modification by small protein removal →	+0.055	+0.588	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.084	+0.668	.006	.001	2	13
BLOOD_Myeloma	Protein deubiquitination →	+0.049	+0.838	.005	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.074	+0.863	<.001	<.001	3	11
BLOOD_Lymphoma	Regulation of centriole replication →	+0.081	+0.988	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

Regulation of sister chromatid cohesion by IKZF5 expression — SOFT_TISSUE

Explore this box plot interactively →