IKZF5

Across TCGA cell cohorts, IKZF5 mutation is significantly associated with the mutation status of many other genes, with 2,548 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IKZF5-associated genes across cancer lineages are FYN, RUFY3, and ACOX3. Each is linked with IKZF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF5-to-partner and partner-to-IKZF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FYN grouped by IKZF5-low versus IKZF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF5→partner) and Y-score (partner→IKZF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FYN →	+2.630	+3.047	.005	.005	1	2
LARGE_INTESTINE	RUFY3 →	+5.215	+4.159	<.001	<.001	1	2
LARGE_INTESTINE	ACOX3 →	+2.893	+3.222	.003	.003	1	2
LARGE_INTESTINE	ERP29 →	+3.799	+3.329	.005	.005	1	2
LARGE_INTESTINE	CCNK →	+3.215	+3.415	.002	.002	1	2
LARGE_INTESTINE	MTMR3 →	+3.630	+3.630	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,548 associations by consensus.

FYN by IKZF5 expression — LARGE_INTESTINE

Explore this box plot interactively →