IKZF4

Across TCGA patient cohorts, IKZF4 mutation is significantly associated with the RNA expression of many other genes, with 4,882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF4-associated genes across cancer lineages are NPM3, MRPS15, and LIAS. Each is linked with IKZF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IKZF4-to-partner and partner-to-IKZF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPM3 grouped by IKZF4-low versus IKZF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF4→partner) and Y-score (partner→IKZF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPM3 →	+0.402	+1.922	.007	.009	3	3
UCEC	MRPS15 →	+0.443	+2.627	<.001	<.001	3	3
UCEC	LIAS →	+0.473	+2.378	<.001	<.001	3	3
UCEC	ITGB3BP →	+0.462	+1.820	<.001	.001	3	3
UCEC	PITHD1 →	+0.454	+2.069	<.001	<.001	3	3
UCEC	DNAJC9 →	+0.702	+3.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,882 associations by consensus.

NPM3 by IKZF4 expression — UCEC

Explore this box plot interactively →