IKZF4

Across TCGA patient cohorts, IKZF4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF4-associated genes across cancer lineages are Cyclin-E2, eIF4E, and JNK_pT183_Y185. Each is linked with IKZF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF4-to-partner and partner-to-IKZF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by IKZF4-low versus IKZF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF4→partner) and Y-score (partner→IKZF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.177	+2.009	.002	.005	3	2
UCEC	eIF4E →	+0.197	+3.335	.008	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.194	-2.000	.001	.009	3	2
UCEC	MAPK_pT202_Y204 →	-0.456	-1.807	.005	.025	3	2
UCEC	Notch1 →	+0.172	+2.232	<.001	.005	3	2
UCEC	p62 Lck ligand →	+0.427	+2.512	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Cyclin-E2 by IKZF4 expression — UCEC

Explore this box plot interactively →