IKZF4

Across TCGA cell cohorts, IKZF4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IKZF4-associated genes across cancer lineages are KRTAP1-4, OR2M2, and IL17A. Each is linked with IKZF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF4-to-partner and partner-to-IKZF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-4 grouped by IKZF4-low versus IKZF4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF4→partner) and Y-score (partner→IKZF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1
LUNG_SCLC	OR2M2 →	+0.118	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	IL17A →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KRTAP1-4 by IKZF4 expression — OESOPHAGUS

Explore this box plot interactively →