Across TCGA pan-cancer cohorts, IKZF1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IKZF1 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IKZF1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IKZF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ESCA, UCEC, and SKCM are the cancer types where IKZF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.130	0.539	<.001	27	view →
UCEC	DFS	Median	All	0.924	0.615	.007	22	view →
SKCM	OS	Median	III,IV	1.000	0.660	.007	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LGG	OS	Median	All	0.396	0.831	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IKZF1 tumor-vs-normal RNA expression · all IKZF1 data types