Across TCGA pan-cancer cohorts, IKZF1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IKZF1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where IKZF1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IKZF1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where IKZF1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKZF1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.858	<.001	11	view →
COAD	All	III,IV	−1.919	<.001	8	view →
HNSC	All	All	+0.195	.020	3	view →
LUAD	All	All	+0.135	.002	3	view →
PDAC	All	IV	−1.320	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IKZF1 RNA expression & survival · all IKZF1 data types