Across TCGA patient cohorts, IKZF1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,320 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IKZF1-associated genes across cancer lineages are IL10RA, CD53, and NCF1C. Each is linked with IKZF1 in more than 8 cancer types. Because this analysis shows association rather than direction, both IKZF1-to-partner and partner-to-IKZF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF1→partner) and Y-score (partner→IKZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL10RA →	+1.084	+0.783	<.001	<.001	3	9
OV	CD53 →	+1.413	+0.766	.003	.001	3	9
UCEC	NCF1C →	+1.207	+0.533	<.001	<.001	3	9
LSCC	CCDC69 →	+1.162	+0.809	<.001	<.001	3	9
OV	LST1 →	+1.201	+0.666	<.001	.007	3	9
BRCA	TRAV19 →	+1.015	+0.559	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,320 associations by consensus.

Exploration

IKZF1 survival (RNA) · tumor vs normal (RNA) · all IKZF1 data types