Across TCGA patient cohorts, IKZF1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF1-associated genes across cancer lineages are STAT3_pY705, ERK2, and TFRC. Each is linked with IKZF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IKZF1-to-partner and partner-to-IKZF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF1→partner) and Y-score (partner→IKZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.278	-1.463	<.001	.005	3	4
UCEC	ERK2 →	+0.127	+1.206	.017	.009	3	3
UCEC	TFRC →	+0.294	+1.362	.044	.034	3	3
SKCM	Cyclin-B1 →	+0.524	+3.012	<.001	<.001	3	2
UCEC	IGFBP2 →	-0.544	-1.584	.002	.015	3	2
UCEC	MEK1 →	+0.276	+1.415	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

IKZF1 survival (RNA) · tumor vs normal (RNA) · all IKZF1 data types