Across TCGA cell cohorts, IKZF1 mutation is significantly associated with the RNA expression of many other genes, with 528 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IKZF1-associated genes across cancer lineages are RNF215, TTC21B, and RNF185. Each is linked with IKZF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IKZF1-to-partner and partner-to-IKZF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF1→partner) and Y-score (partner→IKZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF215 →	+0.972	+3.237	<.001	.003	3	3
LARGE_INTESTINE	TTC21B →	+0.538	+3.234	.002	.004	3	2
LARGE_INTESTINE	RNF185 →	+0.476	+3.064	.001	.009	2	3
BLOOD_Leukemia	NTRK3 →	+0.954	+3.438	.002	.004	3	2
LARGE_INTESTINE	CCDC40 →	+0.762	+2.628	.003	.002	3	2
LARGE_INTESTINE	FAM227A →	+0.527	+3.321	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 528 associations by consensus.

Exploration

IKZF1 survival (RNA) · tumor vs normal (RNA) · all IKZF1 data types