IKBKE

Across TCGA pan-cancer cohorts, IKBKE mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IKBKE’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where IKBKE mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IKBKE is over-expressed in tumor.

LSCC, HNSC, and CCRCC are the cancer types where IKBKE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKBKE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.251	<.001	5	view →
HNSC	All	II,III,IV	+0.183	.022	4	view →
CCRCC	Male	All	+0.636	.008	3	view →
LUAD	Female	II,III,IV	+0.181	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IKBKE–LSCC

Open the LSCC breakdown →