IKBIP

Across TCGA pan-cancer cohorts, IKBIP Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IKBIP data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher IKBIP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IKBIP expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

SCLC, BLCA, and KIRC are the cancer types where IKBIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
BLCA	DFS	Median	II,III,IV	0.793	0.326	.024	12	view →
KIRC	OS	Median	All	0.263	0.810	.015	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	DFS	Median	All	0.922	0.626	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IKBIP–SCLC (OS)

Open the SCLC breakdown →