IKBIP

Across TCGA pan-cancer cohorts, IKBIP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IKBIP data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IKBIP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IKBIP expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where IKBIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.191	0.391	<.001	49	view →
CCRCC	DFS	Median	III,IV	0.378	0.812	<.001	48	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	12	view →
GBM	DFS	Median	All	0.646	0.783	.009	8	view →
LSCC	DFS	Median	All	0.627	0.794	.028	5	view →
LUAD	DFS	Tertile	All	0.959	0.865	.024	4	view →
HNSC	DFS	Median	IV	0.673	0.873	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IKBIP–PDAC (DFS)

Open the PDAC breakdown →