IKBIP

Across TCGA patient cohorts, IKBIP mutation is significantly associated with the RNA expression of many other genes, with 965 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBIP-associated genes across cancer lineages are RNU6-1127P, RNU7-119P, and CCL5. Each is linked with IKBIP in more than 2 cancer types. Because this analysis shows association rather than direction, both IKBIP-to-partner and partner-to-IKBIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1127P grouped by IKBIP-low versus IKBIP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBIP→partner) and Y-score (partner→IKBIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1127P →	+0.443	+5.306	<.001	<.001	3	3
COAD	RNU7-119P →	+0.673	+4.399	<.001	.006	3	3
UCEC	CCL5 →	+1.198	+4.016	<.001	<.001	3	2
UCEC	CCL4 →	+0.871	+2.592	<.001	<.001	3	2
HNSC	SNORD32B →	+0.224	+5.357	<.001	.001	3	2
HNSC	RNU6-33P →	+0.478	+3.733	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

RNU6-1127P by IKBIP expression — COAD

Explore this box plot interactively →