IKBIP

Across TCGA patient cohorts, IKBIP mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKBIP-associated genes across cancer lineages are FoxM1, INPP4B, and Ku80. Each is linked with IKBIP in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBIP-to-partner and partner-to-IKBIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IKBIP-low versus IKBIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBIP→partner) and Y-score (partner→IKBIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.224	+2.009	.011	.005	3	2
UCEC	INPP4B →	-0.267	-2.115	.015	.016	3	2
UCEC	Ku80 →	+0.228	+1.261	.004	.029	3	2
UCEC	Myosin-IIa_pS1943 →	+0.185	+2.150	.008	<.001	3	2
UCEC	p62 Lck ligand →	+0.254	+1.916	.021	.009	3	2
UCEC	ASNS →	+0.443	+1.807	<.001	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FoxM1 by IKBIP expression — UCEC

Explore this box plot interactively →