IKBIP

Across TCGA cell cohorts, IKBIP mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IKBIP-associated genes across cancer lineages are TBC1D21, DACH2, and PROP1. Each is linked with IKBIP in more than 1 cancer types. Because this analysis shows association rather than direction, both IKBIP-to-partner and partner-to-IKBIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by IKBIP-low versus IKBIP-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBIP→partner) and Y-score (partner→IKBIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TBC1D21 →	+0.076	+4.129	<.001	.007	3	2
BLOOD_Leukemia	DACH2 →	+0.268	+3.944	.002	.006	3	1
BLOOD_Leukemia	PROP1 →	+0.018	+3.874	.009	.005	3	1
BLOOD_Leukemia	SMIM36 →	+0.088	+4.269	<.001	.002	3	1
BLOOD_Leukemia	OR1D5 →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DMRTC1 →	+0.201	+3.855	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

TBC1D21 by IKBIP expression — STOMACH

Explore this box plot interactively →