IKBIP

Across TCGA cell cohorts, IKBIP mutation is significantly associated with the mutation status of many other genes, with 2,696 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IKBIP-associated genes across cancer lineages are IGSF22, SULF2, and CCDC74B. Each is linked with IKBIP in more than 3 cancer types. Because this analysis shows association rather than direction, both IKBIP-to-partner and partner-to-IKBIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF22 grouped by IKBIP-low versus IKBIP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKBIP→partner) and Y-score (partner→IKBIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IGSF22 →	+1.895	+2.392	.006	.006	1	4
BLOOD_Leukemia	SULF2 →	+3.063	+3.498	.006	.006	1	4
LUNG_NSCLC_LUAD	CCDC74B →	+5.339	+4.772	.004	.004	1	4
STOMACH	VPS13A →	+3.357	+4.285	.005	.005	1	4
LARGE_INTESTINE	SBNO2 →	+1.895	+2.392	.006	.006	1	4
BLOOD_Leukemia	THSD1 →	+3.063	+3.498	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,696 associations by consensus.

IGSF22 by IKBIP expression — LARGE_INTESTINE

Explore this box plot interactively →