IK

Across TCGA pan-cancer cohorts, IK Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IK data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IK expression acts as an unfavorable survival marker.

LUAD, BRCA, and SKCM are the cancer types where IK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.236	0.812	.001	15	view →
BRCA	OS	Median	All	0.107	0.578	.004	12	view →
SKCM	DFS	Median	III,IV	0.130	0.601	.003	10	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
KIRP	OS	Median	All	0.680	0.948	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IK–LUAD (OS)

Open the LUAD breakdown →