IK

Across TCGA pan-cancer cohorts, IK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IK data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IK expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where IK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.887	0.461	.002	23	view →
PDAC	DFS	Tertile	All	0.885	0.676	.004	17	view →
GBM	OS	Quartile	All	0.523	0.292	.014	14	view →
COAD	DFS	Tertile	All	1.000	0.864	.045	12	view →
HNSC	DFS	Tertile	IV	0.553	0.798	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IK–LUAD (DFS)

Open the LUAD breakdown →