IK

Across TCGA patient cohorts, IK protein abundance is significantly associated with the protein abundance of many other proteins, with 32,440 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IK-associated proteins across cancer lineages are GTF2F2, ALYREF, and HCFC1. Each is linked with IK in more than 9 cancer types. Because this analysis shows association rather than direction, both IK-to-partner and partner-to-IK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IK versus GTF2F2 in GBM, with a Pearson correlation of 0.73.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IK→partner) and Y-score (partner→IK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GTF2F2 →	+0.503	+0.351	<.001	<.001	3	10
GBM	ALYREF →	+0.405	+0.364	<.001	<.001	3	10
GBM	HCFC1 →	+0.321	+0.367	<.001	<.001	3	10
OV	HNRNPA0 →	+0.495	+0.200	<.001	<.001	3	10
OV	HNRNPA2B1 →	+0.243	+0.191	<.001	<.001	3	10
HNSC	HNRNPA3 →	+0.365	+0.171	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 32,440 associations by consensus.

IK vs GTF2F2 — GBM

Explore this scatter interactively →