IK

Across TCGA cell cohorts, IK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,635 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IK-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Negative regulation of chromosome organization, and Metaphase/anaphase transition of cell cycle. Each is linked with IK in more than 13 cancer types. Because this analysis shows association rather than direction, both IK-to-partner and partner-to-IK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by IK-low versus IK-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IK→partner) and Y-score (partner→IK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of DNA-templated transcription initiation →	+0.061	+0.766	<.001	.009	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.133	+1.036	<.001	<.001	3	14
BONE	Metaphase/anaphase transition of cell cycle →	+0.190	+0.554	<.001	<.001	3	14
KIDNEY	Protein-RNA covalent cross-linking repair →	+0.099	+0.903	.001	.003	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to centrosome →	+0.086	+0.718	.001	.001	3	13
URINARY_TRACT	Transcription preinitiation complex assembly →	+0.071	+0.798	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,635 associations by consensus.

Regulation of DNA-templated transcription initiation by IK expression — KIDNEY

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