IK

Across TCGA cell cohorts, IK mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IK-associated genes across cancer lineages are KRTAP10-4, GGA1, and DESI1. Each is linked with IK in more than 1 cancer types. Because this analysis shows association rather than direction, both IK-to-partner and partner-to-IK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-4 grouped by IK-low versus IK-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IK→partner) and Y-score (partner→IK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRTAP10-4 →	+0.029	+5.321	<.001	.005	3	1
LARGE_INTESTINE	GGA1 →	+0.630	+3.212	.005	.006	3	1
LARGE_INTESTINE	DESI1 →	+0.571	+3.299	<.001	.004	3	1
LARGE_INTESTINE	HINT3 →	+0.851	+3.212	<.001	.006	3	1
LARGE_INTESTINE	MBD1 →	+0.729	+3.385	.009	.004	3	1
LARGE_INTESTINE	F13B →	+0.062	+3.035	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

KRTAP10-4 by IK expression — CNS

Explore this box plot interactively →