IGSF9B

Across TCGA patient cohorts, IGSF9B mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF9B-associated genes across cancer lineages are 4E-BP1, PCNA, and PDCD4. Each is linked with IGSF9B in more than 3 cancer types. Because this analysis shows association rather than direction, both IGSF9B-to-partner and partner-to-IGSF9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by IGSF9B-low versus IGSF9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF9B→partner) and Y-score (partner→IGSF9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.229	+1.745	.001	.001	3	4
UCEC	PCNA →	+0.166	+1.584	.003	.002	3	3
COAD	PDCD4 →	-0.525	-2.450	<.001	<.001	3	3
COAD	ASNS →	+0.487	+1.765	<.001	.012	3	3
BLCA	Beclin →	+0.154	+2.187	.009	.032	3	2
LUSC	MYH11 →	-1.033	-2.450	.011	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

4E-BP1 by IGSF9B expression — UCEC

Explore this box plot interactively →