IGSF9

Across TCGA patient cohorts, IGSF9 mutation is significantly associated with the RNA expression of many other genes, with 6,769 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF9-associated genes across cancer lineages are ASZ1, COX5BP8, and CCAR2. Each is linked with IGSF9 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF9-to-partner and partner-to-IGSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by IGSF9-low versus IGSF9-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF9→partner) and Y-score (partner→IGSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ASZ1 →	+0.307	+3.009	<.001	.009	3	3
HNSC	COX5BP8 →	+0.087	+5.111	.001	.004	3	3
UCEC	CCAR2 →	+0.386	+2.946	<.001	<.001	3	3
UCEC	ARF6 →	+0.495	+2.412	<.001	<.001	3	3
UCEC	ZFYVE19 →	+0.381	+1.595	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.586	+2.673	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,769 associations by consensus.

ASZ1 by IGSF9 expression — BLCA

Explore this box plot interactively →