IGSF9

Across TCGA patient cohorts, IGSF9 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF9-associated genes across cancer lineages are eIF4E, MEK1, and p38-MAPK_pT180_Y182. Each is linked with IGSF9 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF9-to-partner and partner-to-IGSF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IGSF9-low versus IGSF9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF9→partner) and Y-score (partner→IGSF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.163	+2.087	.004	.004	3	2
UCEC	MEK1 →	+0.376	+2.050	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.330	-1.700	.014	.040	3	2
UCEC	PCNA →	+0.220	+1.807	<.001	<.001	3	2
COAD	Paxillin →	-0.505	-2.991	.005	.036	3	1
COAD	ASNS →	+0.502	+3.008	.014	.019	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by IGSF9 expression — SKCM

Explore this box plot interactively →