IGSF8

Across TCGA patient cohorts, IGSF8 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,226 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF8-associated proteins across cancer lineages are FAM114A2, FKBP11, and SET_S7. Each is linked with IGSF8 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF8 versus FAM114A2 in LSCC, with a Pearson correlation of -0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM114A2 →	-0.216	-0.507	.002	.001	3	4
GBM	FKBP11 →	-0.696	-0.737	<.001	<.001	3	4
OV	SET_S7 →	-0.500	-0.586	.009	.002	3	4
GBM	ARHGEF11 →	+0.179	+0.729	<.001	<.001	3	4
LUAD	PRCC →	+0.281	+0.608	<.001	<.001	3	3
GBM	RAB27A →	-0.550	-0.536	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,226 associations by consensus.

IGSF8 vs FAM114A2 — LSCC

Explore this scatter interactively →