IGSF8

Across TCGA patient cohorts, IGSF8 protein abundance is significantly associated with the RNA expression of many other genes, with 5,262 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGSF8-associated genes across cancer lineages are CDKN1C, ADK, and ABHD17B. Each is linked with IGSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGSF8 versus CDKN1C in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDKN1C →	+0.872	+0.291	.002	<.001	3	3
HNSC	ADK →	-0.656	-0.219	.002	.006	3	3
GBM	ABHD17B →	+0.383	+0.485	<.001	<.001	3	3
UCEC	PLEKHA1 →	+0.501	+0.420	.004	.002	3	3
OV	SECISBP2L →	+0.615	+0.381	.002	<.001	3	3
GBM	DENND10P1 →	+0.086	+0.411	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,262 associations by consensus.

IGSF8 vs CDKN1C — COAD

Explore this scatter interactively →