IGSF8

Across TCGA patient cohorts, IGSF8 mutation is significantly associated with the RNA expression of many other genes, with 2,204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF8-associated genes across cancer lineages are RACGAP1, IGHD6-6, and HMGXB4. Each is linked with IGSF8 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RACGAP1 grouped by IGSF8-low versus IGSF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RACGAP1 →	+0.715	+3.343	.002	.005	3	5
CESC	IGHD6-6 →	+1.627	+4.760	<.001	.003	3	3
UCEC	HMGXB4 →	+0.478	+3.502	.005	.002	3	3
UCEC	FAM83D →	+0.870	+2.010	.003	.006	3	3
UCEC	GTF2H3 →	+0.723	+3.595	<.001	.001	3	3
UCEC	PPP2CA →	+0.349	+2.053	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,204 associations by consensus.

RACGAP1 by IGSF8 expression — UCEC

Explore this box plot interactively →