IGSF8

Across TCGA patient cohorts, IGSF8 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF8-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and STAT3_pY705. Each is linked with IGSF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF8-to-partner and partner-to-IGSF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IGSF8-low versus IGSF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF8→partner) and Y-score (partner→IGSF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.237	+2.906	.008	.001	3	2
UCEC	mTOR_pS2448 →	-0.156	-1.980	.013	.030	3	2
UCEC	STAT3_pY705 →	-0.386	-2.574	<.001	.010	3	2
UCEC	ERK2 →	+0.170	+2.999	.037	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.151	-3.459	.004	.005	3	1
UCEC	Ku80 →	+0.270	+1.713	.007	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by IGSF8 expression — UCEC

Explore this box plot interactively →